美国洛克菲勒大学Elaine Fuchs研究组发现干细胞驱动的淋巴重建协调组织再生。 相关论文于10月31日在线发表在国际学术期刊《科学》上。

研究人员确定淋巴管毛细血管是关键的干细胞（SC）小生境组件。 在皮肤中，淋巴管在毛囊（HF）SC周围形成紧密的网络。 当HF再生时，淋巴：SC连接动态变化。 研究人员还揭示了控制淋巴行为SC中的一个分泌组开关。 静息的SC表达血管样生成素7（Angptl7），促进淋巴引流。 激活的SC切换到Angptl4，触发短暂的淋巴解离并减少引流。 当淋巴管受到干扰或分泌组开关被破坏时，HF循环早熟并且组织再生变得不同步。

在揭示淋巴毛细血管作为SC小生境的关键元素过程中，研究人员还了解了SC如何协调它们在整个组织中的活动。

据了解，组织依赖于干细胞（SCs）进行体内稳态和伤口修复。 SC位于特殊的微环境（小生境）中，其复杂性以及在协调组织生长中的作用仍待阐明。

附：英文原文

Title: Stem cell–driven lymphatic remodeling coordinates tissue regeneration

Author: Shiri Gur-Cohen, Hanseul Yang, Sanjeethan C. Baksh, Yuxuan Miao, John Levorse, Raghu P. Kataru, Xiaolei Liu, June de la Cruz-Racelis, Babak J. Mehrara, Elaine Fuchs

Issue&Volume: 2019/10/31

Abstract: AbstractTissues rely on stem cells (SCs) for homeostasis and wound-repair. SCs reside in specialized microenvironments (niches) whose complexities and roles in orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC-niche components. In skin, lymphatics form intimate networks around hair follicle (HF) SCs. When HFs regenerate, lymphatic:SC connections become dynamic. We unravel a secretome switch within SCs that controls lymphatic behavior. Resting SCs express Angiopoietin-like 7 (Angptl7), promoting lymphatic drainage. Activated SCs switch to Angptl4, triggering transient lymphatic dissociation and reduced drainage. When lymphatics are perturbed or the secretome switch is disrupted, HFs cycle precociously and tissue regeneration becomes asynchronous. In unearthing lymphatic capillaries as a critical SC-niche element, we have learned how SCs coordinate their activity across a tissue.

DOI: 10.1126/science.aay4509

Source: https://science.sciencemag.org/content/early/2019/10/30/science.aay4509