美国纪念斯隆-凯特琳癌症中心Clarissa Campbell和Alexander Rudensky合作综述了调节性T细胞在组织病理生理和代谢中的作用。该综述2019年10月10日在线发表于《细胞——代谢》。

研究人员介绍表达X染色体编码的转录因子Foxp3的调节性T（Treg）细胞代表一种特殊的免疫抑制细胞系，具有公认的预防致命性自身免疫和炎症的基本功能。 最近的研究表明，Treg细胞还可以对新陈代谢发挥系统性作用，参与组织修复，提示这些细胞在服务和保护组织中具有双重作用。

在这篇文章中，研究人员综述了Treg细胞支持组织功能和维持机体稳态的多种手段。

附：英文原文

of Regulatory T Cells in Tissue Pathophysiology and Metabolism

Author: Clarissa Campbell, Alexander Rudensky

Issue&Volume: 10 October 2019

Abstract: 

Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.

DOI: 10.1016/j.cmet.2019.09.010

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30513-3